Pioneering doctor  Hanaoka Seishū 華岡 青洲, of the Edo period, combined his knowledge of Chinese herbal medicine with Western surgical techniques he had learned, and became the first to perform surgeries with anesthetic. He was the first to formulate and use general anesthesia to remove tumors from cancer patients. His proceedure came 50 years before anyone else would perform surgery with general anesthetic. In the medical manuscript (example seen above), hand-painted pictures visually document the likeness to the men and women patients who went to Hanaoka for treatment, as well as the medical conditions being treated.  https://youtu.be/RNGfown7iys